deoxyhypusine synthase
Enzyme information
Common names
deoxyhypusine synthase
spermidine:eIF5A-lysine 4-aminobutyltransferase (propane-1,3-diamine-forming)
2.5.1.46
EC Number
2.5.1.46
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Reactions
Spermidine + [eIF5A-precursor]-lysine = 1,3-Diaminopropane + [eIF5A-precursor]-deoxyhypusine
NAD+ + Spermidine = NADH + H+ + Dehydrospermidine
NADH + H+ + N-(4-Aminobutylidene)-[eIF5A-precursor]-lysine = NAD+ + [eIF5A-precursor]-deoxyhypusine
[eIF5A-precursor]-lysine + Dehydrospermidine = 1,3-Diaminopropane + N-(4-Aminobutylidene)-[eIF5A-precursor]-lysine