catechol O-methyltransferase
Enzyme information
Common names
catechol O-methyltransferase
COMT I
COMT II
S-COMT (soluble form of catechol-O-methyltransferase)
MB-COMT (membrane-bound form of catechol-O-methyltransferase)
catechol methyltransferase
catecholamine O-methyltransferase
2.1.1.6
EC Number
2.1.1.6
Links
Reactions
S-Adenosyl-L-methionine + Catechol = S-Adenosyl-L-homocysteine + o-Methoxyphenol
S-Adenosyl-L-methionine + L-Noradrenaline = S-Adenosyl-L-homocysteine + L-Normetanephrine
S-Adenosyl-L-methionine + L-Adrenaline = S-Adenosyl-L-homocysteine + L-Metanephrine
S-Adenosyl-L-methionine + 3,4-Dihydroxyphenylacetate = S-Adenosyl-L-homocysteine + Homovanillate
S-Adenosyl-L-methionine + Dopamine = S-Adenosyl-L-homocysteine + 3-Methoxytyramine
S-Adenosyl-L-methionine + 2-Hydroxyestrone = S-Adenosyl-L-homocysteine + 2-Methoxyestrone
S-Adenosyl-L-methionine + 2-Hydroxyestradiol = S-Adenosyl-L-homocysteine + 2-Methoxyestradiol-17beta
S-Adenosyl-L-methionine + 3,4-Dihydroxyphenylethyleneglycol = S-Adenosyl-L-homocysteine + 3-Methoxy-4-hydroxyphenylethyleneglycol
S-Adenosyl-L-methionine + 3,4-Dihydroxymandelate = S-Adenosyl-L-homocysteine + 3-Methoxy-4-hydroxymandelate
S-Adenosyl-L-methionine + Catechol = S-Adenosyl-L-homocysteine + Guaiacol