alpha-ketoisovalerate dehydrogenase
Enzyme information
Common names
alpha-ketoisovalerate dehydrogenase
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
2-oxoisocaproate dehydrogenase
2-oxoisovalerate (lipoate) dehydrogenase
3-methyl-2-oxobutanoate dehydrogenase (lipoamide)
3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating)
alpha-keto-alpha-methylvalerate dehydrogenase
alpha-ketoisocaproate dehydrogenase
alpha-ketoisocaproic dehydrogenase
alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase
alpha-oxoisocaproate dehydrogenase
BCKDH
BCOAD
branched chain keto acid dehydrogenase
branched-chain (-2-oxoacid) dehydrogenase (BCD)
branched-chain 2-keto acid dehydrogenase
branched-chain 2-oxo acid dehydrogenase
branched-chain alpha-keto acid dehydrogenase
branched-chain alpha-oxo acid dehydrogenase
branched-chain keto acid dehydrogenase
branched-chain ketoacid dehydrogenase
dehydrogenase, 2-oxoisovalerate (lipoate)
dehydrogenase, branched chain alpha-keto acid
1.2.4.4
EC Number
1.2.4.4
Links
Reactions
3-Methyl-2-oxobutanoic acid + Enzyme N6-(lipoyl)lysine = CO2 + [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine
4-Methyl-2-oxopentanoate + Enzyme N6-(lipoyl)lysine = CO2 + [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine
(S)-3-Methyl-2-oxopentanoic acid + Enzyme N6-(lipoyl)lysine = CO2 + [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine
Thiamin diphosphate + 3-Methyl-2-oxobutanoic acid = CO2 + 2-Methyl-1-hydroxypropyl-ThPP
Enzyme N6-(lipoyl)lysine + 2-Methyl-1-hydroxypropyl-ThPP = Thiamin diphosphate + [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine
Thiamin diphosphate + 4-Methyl-2-oxopentanoate = CO2 + 3-Methyl-1-hydroxybutyl-ThPP
Enzyme N6-(lipoyl)lysine + 3-Methyl-1-hydroxybutyl-ThPP = Thiamin diphosphate + [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine
Thiamin diphosphate + (S)-3-Methyl-2-oxopentanoic acid = CO2 + 2-Methyl-1-hydroxybutyl-ThPP
Enzyme N6-(lipoyl)lysine + 2-Methyl-1-hydroxybutyl-ThPP = Thiamin diphosphate + [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine