oxoglutarate decarboxylase
Enzyme information
Common names
oxoglutarate decarboxylase
oxoglutarate dehydrogenase (succinyl-transferring)
2-ketoglutarate dehydrogenase
2-oxoglutarate dehydrogenase
2-oxoglutarate: lipoate oxidoreductase
2-oxoglutarate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-succinylating)
alpha-ketoglutarate dehydrogenase
alphaketoglutaric acid dehydrogenase
alpha-ketoglutaric dehydrogenase
alpha-oxoglutarate dehydrogenase
AKGDH
OGDC
ketoglutaric dehydrogenase
oxoglutarate dehydrogenase
oxoglutarate dehydrogenase (lipoamide)
1.2.4.2
EC Number
1.2.4.2
Links
Reactions
2-Oxoglutarate + Thiamin diphosphate = CO2 + 3-Carboxy-1-hydroxypropyl-ThPP
2-Oxoglutarate + Enzyme N6-(lipoyl)lysine = CO2 + [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
NAD+ + CoA + 2-Oxoadipate = NADH + CO2 + H+ + Glutaryl-CoA
2-Oxoadipate + Enzyme N6-(lipoyl)lysine = CO2 + [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine
3-Carboxy-1-hydroxypropyl-ThPP + Enzyme N6-(lipoyl)lysine = Thiamin diphosphate + [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
NAD+ + CoA + 2-Oxoglutarate = NADH + CO2 + H+ + Succinyl-CoA