unspecific monooxygenase
Enzyme information
Common names
unspecific monooxygenase
microsomal monooxygenase
xenobiotic monooxygenase
aryl-4-monooxygenase
aryl hydrocarbon hydroxylase
microsomal P-450
flavoprotein-linked monooxygenase
flavoprotein monooxygenase
1.14.14.1
EC Number
1.14.14.1
Links
Reactions
Oxygen + Androstenedione + Reduced flavoprotein = H2O + Oxidized flavoprotein + 19-Hydroxyandrost-4-ene-3,17-dione
Oxygen + Androstenedione + Reduced flavoprotein = H2O + Oxidized flavoprotein + 7alpha-Hydroxyandrost-4-ene-3,17-dione
H2O + Formate + Estrone + Oxidized flavoprotein = Oxygen + Reduced flavoprotein + 19-Oxoandrost-4-ene-3,17-dione
NADH + Oxygen + H+ + Estrone = H2O + NAD+ + 2-Hydroxyestrone
NADPH + Oxygen + H+ + Estrone = H2O + NADP+ + 2-Hydroxyestrone
NADPH + Oxygen + H+ + Estrone = H2O + NADP+ + 16alpha-Hydroxyestrone
Oxygen + Testosterone + Reduced flavoprotein = H2O + Oxidized flavoprotein + 19-Hydroxytestosterone
Oxygen + Testosterone + Reduced flavoprotein = H2O + Oxidized flavoprotein + 7alpha-Hydroxytestosterone
H2O + Formate + Estradiol-17beta + Oxidized flavoprotein = Oxygen + Reduced flavoprotein + 19-Oxotestosterone
NADH + Oxygen + H+ + Estradiol-17beta = H2O + NAD+ + 2-Hydroxyestradiol
NADPH + Oxygen + H+ + Estradiol-17beta = H2O + NADP+ + Estriol
NADPH + Oxygen + H+ + Estradiol-17beta = H2O + NADP+ + 2-Hydroxyestradiol
NADPH + Oxygen + H+ + Dehydroepiandrosterone = H2O + NADP+ + 16alpha-Hydroxydehydroepiandrosterone
Oxygen + Melatonin + Reduced flavoprotein = H2O + Oxidized flavoprotein + 6-Hydroxymelatonin
H2O + Formaldehyde + Morphine + Oxidized flavoprotein = Oxygen + Reduced flavoprotein + Codeine
Oxygen + Fatty acid + Reduced flavoprotein = H2O + Oxidized flavoprotein + alpha-Hydroxy fatty acid
Oxygen + Alkane + Reduced flavoprotein = H2O + ROH + Oxidized flavoprotein
Oxygen + Reduced flavoprotein + 19-Hydroxyandrost-4-ene-3,17-dione = 2 H2O + Oxidized flavoprotein + 19-Oxoandrost-4-ene-3,17-dione
Oxygen + Reduced flavoprotein + 19-Hydroxytestosterone = 2 H2O + Oxidized flavoprotein + 19-Oxotestosterone
Oxygen + Reduced flavoprotein + Parathion = H2O + Sulfur + Oxidized flavoprotein + Paraoxon
NADPH + Oxygen + H+ + Naphthalene = H2O + NADP+ + (1R,2S)-Naphthalene 1,2-oxide
NADPH + Oxygen + H+ + Naphthalene = H2O + NADP+ + (1S,2R)-Naphthalene 1,2-oxide
NADPH + Oxygen + H+ + 1-Nitronaphthalene = H2O + NADP+ + 1-Nitronaphthalene-7,8-oxide
NADPH + Oxygen + H+ + 1-Nitronaphthalene = H2O + NADP+ + 1-Nitronaphthalene-5,6-oxide
15(S)-HPETE = 15H-11,12-EETA
15(S)-HPETE = 11H-14,15-EETA
H2O + 15H-11,12-EETA = 11,12,15-THETA
H2O + 11H-14,15-EETA = 11,14,15-THETA
NADPH + Oxygen + H+ + (5Z,8Z,11Z,14Z)-Icosatetraenoic acid = H2O + NADP+ + 19(S)-HETE
NADPH + Oxygen + H+ + (5Z,8Z,11Z,14Z)-Icosatetraenoic acid = H2O + NADP+ + 14,15-EET
NADPH + Oxygen + H+ + (5Z,8Z,11Z,14Z)-Icosatetraenoic acid = H2O + NADP+ + 11,12-EET
NADPH + Oxygen + H+ + (5Z,8Z,11Z,14Z)-Icosatetraenoic acid = H2O + NADP+ + 8,9-EET
NADPH + Oxygen + H+ + (5Z,8Z,11Z,14Z)-Icosatetraenoic acid = H2O + NADP+ + 5,6-EET
NADPH + Oxygen + H+ + (5Z,8Z,11Z,14Z)-Icosatetraenoic acid = H2O + NADP+ + 16(R)-HETE
NADPH + Oxygen + H+ + Linoleate = H2O + NADP+ + 9(10)-EpOME
NADPH + Oxygen + H+ + Linoleate = H2O + NADP+ + 12(13)-EpOME
NADPH + Oxygen + H+ + Bromobenzene = H2O + NADP+ + Bromobenzene-3,4-oxide
NADPH + Oxygen + H+ + Bromobenzene = H2O + NADP+ + Bromobenzene-2,3-oxide
NADPH + Oxygen + H+ + 4-Bromophenol = H2O + NADP+ + 4-Bromophenol-2,3-epoxide
NADPH + Oxygen + H+ + Benzo[a]pyrene = H2O + NADP+ + Benzo[a]pyrene-9,10-oxide
NADPH + Oxygen + H+ + Benzo[a]pyrene = H2O + NADP+ + Benzo[a]pyrene-7,8-oxide
NADPH + Oxygen + H+ + Benzo[a]pyrene = H2O + NADP+ + Benzo[a]pyrene-4,5-oxide
NADPH + Oxygen + H+ + Benzo[a]pyrene-7,8-diol = H2O + NADP+ + Benzo[a]pyrene-7,8-dihydrodiol-9,10-oxide
NADPH + Oxygen + H+ + 9-Hydroxybenzo[a]pyrene = H2O + NADP+ + 9-Hydroxybenzo[a]pyrene-4,5-oxide
NADPH + Oxygen + H+ + 1,1-Dichloroethylene = H2O + NADP+ + 2,2-Dichloroacetaldehyde
NADPH + Oxygen + H+ + 1,1-Dichloroethylene = H2O + NADP+ + 1,1-Dichloroethylene epoxide
NADPH + Oxygen + H+ + 1,1-Dichloroethylene = H2O + NADP+ + Chloroacetyl chloride
NADPH + Oxygen + H+ + Trichloroethene = H2O + NADP+ + TCE epoxide
NADPH + Oxygen + H+ + Trichloroethene = H2O + NADP+ + Chloral
NADPH + Oxygen + H+ + Trichloroethanol = H2O + NADP+ + Trichloroacetate
NADPH + Oxygen + H+ + 1,2-Dibromoethane = H2O + NADP+ + Hydrobromic acid + 2-Bromoacetaldehyde
NADPH + Oxygen + H+ + Caffeine = H2O + NADP+ + Formaldehyde + 1,7-Dimethylxanthine
1,7-Dimethylxanthine = 1-Methylxanthine
1,7-Dimethylxanthine = 1,7-Dimethyluric acid
Oxygen + Reduced flavoprotein + Tegafur = H2O + Oxidized flavoprotein + 5-FU + Succinic aldehyde
Irinotecan = APC
2 Oxygen + 2 Reduced flavoprotein + Irinotecan = 2 H2O + 2 Oxidized flavoprotein + Glutaral + NPC
Oxygen + Reduced flavoprotein + Codeine = H2O + Formaldehyde + Oxidized flavoprotein + Norcodeine
Oxygen + Morphine + Reduced flavoprotein = H2O + Formaldehyde + Oxidized flavoprotein + Normorphine
NADPH + Oxygen + H+ + Tamoxifen = H2O + NADP+ + Hydroxytamoxifen
Tamoxifen = N-Desmethyltamoxifen
Hydroxytamoxifen = 4-Hydroxy-N-desmethyltamoxifen
NADPH + Oxygen + H+ + N-Desmethyltamoxifen = H2O + NADP+ + 4-Hydroxy-N-desmethyltamoxifen
NADPH + Oxygen + H+ + Tamoxifen = H2O + NADP+ + alpha-Hydroxytamoxifen
N-Desmethyltamoxifen = N,N-Didesmethyltamoxifen
NADPH + Oxygen + H+ + N-Desmethyltamoxifen = H2O + NADP+ + alpha-Hydroxy-N-desmethyltamoxifen
NADPH + Oxygen + H+ + Cyclophosphamide = H2O + NADP+ + 4-Hydroxycyclophosphamide
Cyclophosphamide = Chloroacetaldehyde + Dechloroethylcyclophosphamide
4-Hydroxycyclophosphamide = 4-Ketocyclophosphamide
NADPH + Oxygen + H+ + Ifosfamide = H2O + NADP+ + 4-Hydroxyifosfamide
Ifosfamide = Chloroacetaldehyde + Dechloroethylcyclophosphamide
Ifosfamide = Chloroacetaldehyde + 2-Dechloroethylifosfamide
Lidocaine = Monoethylglycinexylidide
NADPH + Oxygen + H+ + Lidocaine = H2O + NADP+ + 3-Hydroxylidocaine
NADPH + Oxygen + H+ + Felbamate = H2O + NADP+ + p-Hydroxyfelbamate
NADPH + Oxygen + H+ + Felbamate = H2O + NADP+ + 2-Hydroxyfelbamate
NADPH + Oxygen + H+ + Carbamazepine = H2O + NADP+ + Carbamazepine-10,11-epoxide
NADPH + Oxygen + H+ + Carbamazepine = H2O + NADP+ + 3-Hydroxycarbamazepine
2-Hydroxycarbamazepine = 2-Hydroxyiminostilbene
Valproic acid = 2-n-Propyl-4-pentenoic acid
NADPH + Oxygen + H+ + Valproic acid = H2O + NADP+ + 4-Hydroxyvalproic acid
NADPH + Oxygen + H+ + Valproic acid = H2O + NADP+ + 5-Hydroxyvalproic acid
NADPH + Oxygen + H+ + Valproic acid = H2O + NADP+ + 3-Hydroxyvalproic acid
Methadone = EDDP
EDDP = 2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline
Levomethadyl acetate = L-alpha-Acetyl-N-normethadol
L-alpha-Acetyl-N-normethadol = L-alpha-Acetyl-N,N-dinormethadol
Citalopram = Demethylcitalopram
Citalopram = Citalopram N-oxide
Demethylcitalopram = Didemethylcitalopram
NADPH + Oxygen + H+ + Retinoate = H2O + NADP+ + all-trans-18-Hydroxyretinoic acid
NADPH + Oxygen + H+ + Retinoate = H2O + NADP+ + all-trans-5,6-Epoxyretinoic acid
NADPH + Oxygen + H+ + Retinoate = H2O + NADP+ + all-trans-4-Hydroxyretinoic acid
NADPH + Oxygen + H+ + Aflatoxin B1 = H2O + NADP+ + Aflatoxin Q1
NADPH + Oxygen + H+ + Aflatoxin B1 = H2O + NADP+ + Aflatoxin M1
NADPH + Oxygen + H+ + Aflatoxin M1 = H2O + NADP+ + Aflatoxin-M1-8,9-epoxide
NADPH + Oxygen + H+ + Aflatoxin B1 = H2O + NADP+ + Aflatoxin B1-endo-8,9-epoxide
NADPH + Oxygen + H+ + Aflatoxin B1 = H2O + NADP+ + Aflatoxin B1-exo-8,9-epoxide
NADPH + Oxygen + H+ + 7,12-Dimethylbenz[a]anthracene = H2O + NADP+ + 1a,11b-Dihydro-4,9-dimethylbenz[a]anthra[3,4-b]oxirene
NADPH + Oxygen + H+ + trans-3,4-Dihydro-3,4-dihydroxy-7,12-dimethylbenz[a]anthracene = H2O + NADP+ + (1aalpha,2beta,3alpha,11calpha)-1a,2,3,11c-Tetrahydro-6,11-dimethylbenzo[6,7]phenanthro[3,4-b]oxirene-2,3-diol
NADPH + Oxygen + H+ + 4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone = H2O + NADP+ + 4-[(Hydroxymethyl)nitrosoamino]-1-(3-pyridinyl)-1-butanone
NADPH + Oxygen + H+ + 7,12-Dimethylbenz[a]anthracene = H2O + NADP+ + 7-Hydroxymethyl-12-methylbenz[a]anthracene
NADPH + Oxygen + H+ + 7,12-Dimethylbenz[a]anthracene = H2O + NADP+ + 7,12-Dimethylbenz[a]anthracene 5,6-oxide