iodotyrosine deiodinase
Enzyme information
Common names
iodotyrosine deiodinase
iodide peroxidase
iodotyrosine deiodase
iodinase
iodoperoxidase (heme type)
thyroid peroxidase
iodide peroxidase-tyrosine iodinase
monoiodotyrosine deiodinase
thyroperoxidase
tyrosine iodinase
TPO
1.11.1.8
EC Number
1.11.1.8
Links
Reactions
Hydrogen peroxide + 2 H+ + 2 Iodide = 2 H2O + Iodine
Hydrogen peroxide + 2 3,5-Diiodo-L-tyrosine = 2 H2O + O-(4-Hydroxy-3,5-diidophenyl)-3,5-diiodo-L-tyrosine + Dehydroalanine
3-Iodo-L-tyrosine + Hydroiodic acid = L-Tyrosine + Iodine
Hydrogen peroxide + 3,5-Diiodo-L-tyrosine + 3-Iodo-L-tyrosine = 2 H2O + Dehydroalanine + Triiodothyronine
3,5-Diiodo-L-tyrosine + Hydroiodic acid = Iodine + 3-Iodo-L-tyrosine
Iodine + Thyroglobulin L-tyrosine = Hydroiodic acid + Thyroglobulin 3-Iodotyrosine
Iodine + Thyroglobulin 3-Iodotyrosine = Hydroiodic acid + Thyroglobulin 3,5-diiodotyrosine
Hydrogen peroxide + Thyroglobulin 3,5-diiodotyrosine + Thyroglobulin 3-Iodotyrosine = 2 H2O + Thyroglobulin triiodothyronine + Thyroglobulin dehydroalanine
Hydrogen peroxide + 2 Thyroglobulin 3,5-diiodotyrosine = 2 H2O + Thyroglobulin L-thyroxine + Thyroglobulin dehydroalanine